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Top-rated FDA-registered compounding pharmacies ranked by safety certifications, quality standards, and sterile compounding expertise. Find trusted semaglutide sources.
Coreage RX partners with the highest-quality FDA-registered 503B outsourcing facilities, offering third-party tested semaglutide at $99/month. Hims & Hers ($199/mo) also uses premium 503B facilities with rigorous testing. Ro ($99/mo) provides quality 503A pharmacy compounding with comprehensive testing.
503B facilities have stricter FDA oversight than 503A pharmacies and can compound without individual prescriptions. All ranked pharmacies meet safety standards, but 503B facilities offer the highest level of quality assurance.
Understanding the difference between pharmacy types helps you evaluate quality:
Ranked by safety certifications, quality testing, and regulatory compliance
| Rank | Provider | Price | Type | Safety Score | Testing |
|---|---|---|---|---|---|
| #1 | Coreage RX 4.4 | $99/mo | FDA-Registered 503B | 9.5/10 | Yes |
| #2 | Hims & Hers 3.7 | $199/mo | FDA-Registered 503B | 9.0/10 | Yes |
| #3 | Ro Pharmacy 3.9 | $99/mo | FDA-Registered 503A | 8.8/10 | Yes |
| #4 | Remedy Meds 4.2 | $129/mo | FDA-Registered 503B | 8.7/10 | Yes |
| #5 | Orderly Meds 4.3 | $99/mo | FDA-Registered 503A | 8.6/10 | Yes |
| #6 | Henry Meds 4 | $297/mo | FDA-Registered 503B | 8.5/10 | Yes |
| #7 | Strut Health 3.8 | $449/mo | FDA-Registered 503A | 8.3/10 | Yes |
| #8 | Eden 3.6 | $249/mo | FDA-Registered 503A | 8.0/10 | Limited |
Look for FDA-registered facilities, especially 503B outsourcing facilities which face stricter oversight. FDA registration ensures compliance with federal manufacturing standards and regular inspections.
Independent lab testing verifies purity, potency, and sterility of compounded medications. Look for pharmacies that test every batch and provide certificates of analysis.
Injectable medications require sterile compounding in ISO-certified clean rooms following USP <797> standards. This prevents contamination and ensures patient safety.
Current Good Manufacturing Practices (cGMP) are FDA regulations ensuring quality control. 503B facilities must follow cGMP, while 503A pharmacies follow USP standards.
Not all compounding pharmacies meet the same quality standards. Avoid providers that:
Always verify pharmacy credentials and ask about quality testing before purchasing compounded semaglutide.
Compounded semaglutide is a customized version of the medication made by specialized pharmacies using the same active ingredient as brand-name Ozempic and Wegovy. Compounding pharmacies can legally produce semaglutide during FDA-approved drug shortages. It contains the same active pharmaceutical ingredient but costs $99-$299/month instead of $900-$1,400/month for brand versions.
Yes, when produced by properly certified pharmacies. FDA-registered 503B facilities and state-licensed 503A pharmacies must follow strict quality standards. Look for pharmacies that perform third-party testing, maintain sterile compounding capabilities, and comply with cGMP or USP standards. The compounded semaglutide itself is the same molecule as brand-name versions when properly compounded.
503B outsourcing facilities have stricter FDA oversight and must follow current Good Manufacturing Practices (cGMP). They can compound medications in larger batches without individual prescriptions and face regular FDA inspections. 503A pharmacies are traditional compounding pharmacies regulated by state boards, requiring individual prescriptions and following USP standards. Both can produce quality semaglutide, but 503B facilities typically have more rigorous quality controls.
Check these verification steps:
Third-party testing by independent laboratories verifies that compounded semaglutide contains the correct amount of active ingredient (potency), is free from contaminants (purity), and is sterile for injection. This testing provides an objective quality check beyond the pharmacy's own quality control. Reputable pharmacies test every batch and can provide certificates of analysis upon request.
Ask your provider these questions:
When properly compounded and tested, yes. The active ingredient is the same pharmaceutical compound (semaglutide). Quality compounding pharmacies source pharmaceutical-grade ingredients and test to ensure potency matches specifications. Third-party testing verifies that compounded semaglutide contains the stated amount of active ingredient. Many users report similar effectiveness and results with properly compounded semaglutide compared to brand versions.
Price differences reflect various factors: pharmacy type (503B facilities may cost more due to stricter compliance), testing protocols (comprehensive third-party testing adds cost), batch sizes, overhead costs, and provider business models. Extremely low prices may indicate shortcuts in quality testing or sourcing. The $99-$299/month range represents pharmacies meeting safety standards while offering competitive pricing.
FDA allows compounding of shortage drugs under specific provisions. When brand-name semaglutide shortages are resolved, compounding pharmacies may need to transition patients or adjust their offerings based on FDA guidance. Reputable providers will communicate any changes and help patients transition smoothly. Currently, shortages remain ongoing and compounded semaglutide continues to be legally available.
Yes, reputable pharmacies and providers should be transparent about their quality standards. You can request FDA registration numbers for 503B facilities, state pharmacy licenses, certificates of analysis from third-party testing labs, and information about their sterile compounding facilities. Providers who refuse to share this information or are evasive about quality standards should be avoided.
Start with a provider using the highest-quality FDA-registered compounding pharmacies. Your health and safety depend on it.
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